| 產(chǎn)品編號 | bs-0784R |
| 英文名稱 | IFNB1 Rabbit pAb |
| 中文名稱 | 干擾素β抗體 |
| 別 名 | Interferon beta; Fibroblast interferon; IFB; IFF; IFN beta; IFN-beta; IFNB 1; IFNB; Interferon beta 1 fibroblast; Interferon beta precursor; IFNB_HUMAN. IFN-β; IFN β; β-IFN; IFB; β IFN; βIFN. |
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Specific References (5) | bs-0784R has been referenced in 5 publications.
[IF=14.588] Hou L et al. Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity. ACS Nano. 2020 Apr 28;14(4):3927-3940.
[IF=13.273] Weihong Guo. et al. Improved immunotherapy for gastric cancer by nanocomposites with capability of triggering Dual-Damage of Nuclear/Mitochondrial DNA and cGAS/STING-Mediated innate immunity. CHEM ENG J. 2022 Sep;443:136428 WB ; Mouse.
[IF=5.195] Yuxi Liang. et al. The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathway. J ETHNOPHARMACOL. 2023 Jan;300:115743 WB ; Mouse.
[IF=4.432] Pengfei Cheng. et al. A3 adenosine receptor agonist IB-MECA reverses chronic cerebral ischemia-induced inhibitory avoidance memory deficit. Eur J Pharmacol. 2022 Apr;921:174874 WB ; Mouse.
[IF=1.984] Liang Y et al. Astragalus Membranaceus Treatment Protects Raw264. 7 Cells from Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway. Evid Based Complement Alternat Med. 2019 Dec 31;2019:2971604. WB ; Mouse&canine.
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| 研究領(lǐng)域 | 腫瘤 免疫學(xué) 細(xì)菌及病毒 干擾素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human,Mouse (predicted: Rat) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 20 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse IFNB1: 101-184/184 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015] Function: Has antiviral, antibacterial and anticancer activities. Subunit: Monomer. Subcellular Location: Secreted. Similarity: Belongs to the alpha/beta interferon family. Database links: Entrez Gene: 15977 Mouse SwissProt: P01575 Mouse Unigene: 1245 Mouse β型干擾素(Interferon-β,IFN-β)是主要由成纖維細(xì)胞產(chǎn)生的細(xì)胞因子,屬于單一基因編碼產(chǎn)生的蛋白質(zhì),可通過干擾病毒RNA或DNA復(fù)制而抑制病毒生長,并可顯著增強(qiáng)NK細(xì)胞殺傷活性,通過促進(jìn)MHCⅠ類分子表達(dá)而增強(qiáng)CTL對病毒感染細(xì)胞的識別和殺傷作用. |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Raw264.7 (Mouse) Cell Lysate at 30 ug
Lane 2: THP-1 (Human) Cell Lysate at 30 ug
Primary: Anti-IFN beta (bs-0784R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 24 kD
Observed band size: 24 kD
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