| 產(chǎn)品編號(hào) | bs-2484R |
| 英文名稱 | CCL27 Rabbit pAb |
| 中文名稱 | 皮膚T細(xì)胞虜獲趨化因子抗體 |
| 別 名 | ALP; CTACK; C-C motif chemokine 27; CC chemokine ILC; Ccl27; CTAK; Cutaneous T cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL 11 R alpha locus chemokine; IL-11 R-alpha-locus chemokine; PESKY; SCYA27; Skinkine; Small inducible |
| 研究領(lǐng)域 | 免疫學(xué) 趨化因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Cow) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 19 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse CCL27: 25-112/164 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq]. Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10. Subunit: Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization. Subcellular Location: Secreted. Tissue Specificity: Testis, thymus, placenta, ovary and skin. Similarity: Belongs to the intercrine beta (chemokine CC) family. SWISS: Q9Z1X0 Gene ID: 20301 Database links: Entrez Gene: 10850 Human Omim: 604833 Human SwissProt: Q5VZ77 Human SwissProt: Q9Y4X3 Human Unigene: 459590 Human Unigene: 648124 Human CCL27是一種CC型趨化因子，又被稱為Skinkine，ESkine和CTACK。CCL27基因位于人類染色體9，它與皮膚上歸巢的記憶T淋巴細(xì)胞有關(guān)，并在T細(xì)胞介導(dǎo)的皮膚炎癥中起著重要的作用。CCL27表達(dá)在許多組織，包括性腺，胸腺，胎盤和皮膚。其配體為CCR10,CCL27與接觸性軟疣病毒編碼產(chǎn)生的蛋白質(zhì)MC148有較高的同源性，但卻與人皰疹病毒8型編碼產(chǎn)生病毒巨噬細(xì)胞炎癥蛋白-Ⅱ競(jìng)爭(zhēng)結(jié)合受體CCR10。 |
| 產(chǎn)品圖片 |
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-CCL27 Polyclonal Antibody, Unconjugated(bs-2484R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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